Improving Member States preparedness to face an HNS pollution of the Marine System (HNS-MS)
Diphenylmethane Diisocyanate
Description Top
| CAS number | 101-68-8 |
| UN number | 2206 |
| Chemical formula | C15H10N2O2 |
| Standard European Behaviour Classification (SEBC) | Sinker (S) |
GESAMP Hazard profile
| A1 | A2 | B1 | B2 | C1 | C2 | C3 | D1 | D2 | D3 | E1 | E2 | E3 |
| 2 | NR | 0 | 0 | 0 | 0 | 3 | 2 | 2 | SsSr | NI | S | 3 |
Marine pollution Classification (MARPOL Annex II)
| Category | Description |
| Y | Noxious Liquid Substances which, if discharged into the sea from tank cleaning or deballasting operations, are deemed to present a hazard to either marine resources or human health or cause harm to amenities or other legitimate uses of the sea and therefore justify a limitation on the quality and quantity of the discharge into the marine environment. |
Alternate names for this chemical
4,4'-Mdi
1,1'- Methylenebis(4-Isocyanatobenzene)
Methylene Bis (4-Phenyl Isocyanate)
Diphenylmethane Diisocyanate
4,4'- Diisocyanate De Diphenylmethane
1,1'- Methylenebis(4-Isocyanatobenzene)
Methylene Bis (4-Phenyl Isocyanate)
Diphenylmethane Diisocyanate
4,4'- Diisocyanate De Diphenylmethane
Physico-chemical properties Top
| Chemical formula | C15H10N2O2 | |
| Molar mass | 250.26 [g/mol] | |
| State | Solid at 25°C and 1 atm | |
| Fusion temperature | 41 [°C] | |
| Boiling temperature | 364 [°C] | |
| Density |
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| Hydrosolubility |
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| Vapour pressure |
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| Vapour density | 8.5 | |
| Flash point (Pensky-Martens closed cup) | 211 [°C] | |
| Flash point (Cleveland open cup) | 202.22 [°C] | |
| Henry's constant | 0.09 [mol/(m³·Pa)] |
Behaviour Top
| Log Kow | 5.22 |
| Log Koc | 5.45 |
| Hydrolysis (Half-life) | 0.2 day |
| Aqueous photolysis (Half-life) | Not photolysable |
| Standard European Behaviour Classification (SEBC) | Sinker (S) |
Ecotoxicity Top
| Highest no observed effect concentration (NOEC) on crustacean | 10 [mg/l] | |
| Assessment factor (AF) |
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| Predicted No Effect Concentration (PNEC) |
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Hazards Top
Danger
Hazards statements
Health
H315
Causes skin irritation.
H317
May cause an allergic skin reaction.
H319
Causes serious eye irritation.
H332
Harmful if inhaled.
H334
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335
May cause respiratory irritation.
H351
Suspected of causing cancer.
H373
May cause damage to organs through prolonged or repeated exposure, exposure cause the hazard:
Precautionary statements
Prevention
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P285
In case of inadequate ventilation wear respiratory protection.
Response
P302 + P352
IF ON SKIN: Wash with plenty of soap and water.
P304 + P340
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P309 + P311
IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
GESAMP Top
GESAMP Hazard profile
| A1 | A2 | B1 | B2 | C1 | C2 | C3 | D1 | D2 | D3 | E1 | E2 | E3 |
| 2 | NR | 0 | 0 | 0 | 0 | 3 | 2 | 2 | SsSr | NI | S | 3 |
A1: Bioaccumulation
| Rating | Description |
| 2 | Low potential to bioaccumulate |
A1a:
| Rating | Description | Criteria [mg/l] |
| 5 | Very high potential to bioaccumulate | Log Kow ≥ 5 |
A1b:
| Rating | Description | Criteria |
| 2 | Low potential to bioaccumulate | 10 ≤ BCF < 100 |
A2: Biodegradation
| Rating | Description |
| NR | Not readily biodegradable |
B1: Acute aquatic toxicity
| Rating | Description | Criteria [mg/l] |
| 0 | Non-toxic | LC/EC/IC50 > 1000 |
B2: Chronic aquatic toxicity
| Rating | Description | Criteria [mg/l] |
| 0 | Negligible | NOEC > 1 |
C1: Acute oral toxicity
| Rating | Description | Criteria [mg/Kg] |
| 0 | Negligible | AOTE > 2000 |
C2: Acute dermal toxicity (skin contact)
| Rating | Description | Criteria [mg/Kg] |
| 0 | Negligible | ADTE > 2000 |
C3: Acute inhalation toxicity
| Rating | Description | Criteria [mg/l] (4 hours exposure) |
| 3 | Moderately high | 0.5 < AITE ≤ 2 |
D1: Skin irritation or corrosion
| Rating | Description | Sign | GHS category |
| 2 | Irritating | Marked erythema, Obvio | Irritant Category 2 |
D2: Eye irritation
| Rating | Description | Sign | GHS category |
| 2 | Irritating | Marked conjunctival hy | Irritant Category 2A |
D3: Long-term health effects
| Notation | Hazard endpoint | Description | GHS category |
| Ss | Skin Sensitization | Cause specific skin hypersensitivity or allergy following skin contact | Category 1 for Skin Sensitizers |
| Sr | Respiratory Sensitization | Cause specific hypersensitivity of the airways, or asthma, following inhalation | Category 1 for Respiratory Sensitizers |
E1: Tainting of seafood
| Rating | Description |
| NI | No Information |
E2: Behaviour of chemicals in the marine environment
| Rating | Description |
| S | Sinker |
E3: Interference with the use of coastal amenities
| Rating | Interference | Description | Interpretation | Warning |
| 3 | Highly objectionable | 1 is highly acutely toxic; and/or 2 is severely irritant or corrosive to skin or eyes; and/or 3 is carcinogenic, mutagenic or reprotoxic; and/or 4 is a floater or persistent floater with associated health effects | 1 C1 and/or C2 and/or C3 = 4; and/or 2 D1 or D2 = 3, 3A, 3B, or 3C; and/or 3 D3 contains C, M or R; and/or 4 E2 = F or Fp and D3 contains Ss, Sr, T, A, N, or I | Warning issued leading to the closure of amenities |
GHS Security Information
Danger
About the project
HNS-MS is a decision-support tool that Belgian and French maritime authorities as well as coastguard stations can activate in order to forecast the drift, fate and behavior of acute marine pollution by Harmful Noxious Substances (HNS) accidentally released in the marine system.
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Copyright © 2015–2024 HNS-MS Consortium
HNS-MS has been funded by DG-ECHO under agreement ECHO/SUB/2014/693705 and runs from 1 January 2015 to 31 March 2017.